The Biology and Treatment of Cancer – Cancer

Dr. Arthur B. Pardee is one of the best-known cancer researchers and teachers in North America. he has made seminal contributions to understanding gene regulation, growth control, and cell cycle progression. Most recently, the Pardee Laboratory has defined interrelationships between the DNA replication cycle and the mitotic cycle, elucidating important differences between normal and tumor cells. His development of differential display technology has led to the identification of genes aberrantly expressed in cancer as well as broader applications to genes supporting critical regulatory events. He has then translated these fundamental discoveries, exploiting the vulnerability of transformed and tumor cells to biochemical perturbants and the preferential utilization of signaling pathways in tumors to develop novel approaches to cancer chemotherapy. Dr. Pardee is Professor Emeritus at the Dana Farber Cancer Institute and Harvard University, Boston, Mass. Dr. Gary Stein's research has been to discover mechanisms controlling proliferation and differentiation with emphasis on compromised regulation that is linked with disease. He pioneered characterization of transcriptional regulation that mediates cell cycle control. His studies have provided considerable insight into the molecular mechanisms regulating gene expression during the cell cycle in normal and tumor cells. He has been instrumental in defining functional interrelationships between the subnuclear organization of regulatory proteins and gene expression and has made seminal contributions to mechanisms that direct transcription factors to each nuclear site that supports activation or suppression. His recent work has linked fidelity of intranuclear localization of gene regulatory machinery with leukemogenesis and metastasis of breast and prostate cancer. A cancer survivor himself, Dr. Stein is The Gerald and Zelda Haidak Distinguished Professor and Chair of Cell Biology and Professor of Medicine at University of Massachusetts Medical School, Worcester, Mass.

Contributors. Preface. Part I: Introduction. 1. What Goes Wrong In Cancer (Arthur B. Pardee, Gary S. Stein, and Elizabeth A. Bronstein). Part II: Clinical Perspective. 2. Cancer As a Disease: Types of Tumors, Their Frequencies, and Their Progression (Kenneth J. Pienta). 3. Environmental, Genetic, and Viral Causes of Cancer (Rami I. Aqeilan, Nicola Zanesi, and Carlo M. Croce). 4. Diagnosis and Treatment of Malignant Diseases (F. Marc Stewart and Jessica A. Stewart). 5. Clinical Challenges For Treatment and a Cure (Alan Rosmarin). Part III: Cancer Biology. 6. Understanding the Biology of Cancer (Laura A. Lambert, Donald H. Lambert, and Khandan Keyomarski). 7. Mutations and Cell Defenses (Otto S. Gildemeister, Jay M. Sage, and Kendall L. Knight). Part IV: Cancer Diagnosis and Treatment. 8. Cancer Detection and Biomarkers (Arthur B. Pardee and Peng Liang). 9. Clinical Challenges For Treatment and a Cure (Eleni Efstathiou and Christopher J. Logothetis). 10. Clinical Trials in Oncology (Konstantin H. Dragnev and Mark A. Israel). 11. The Development of Drugs: Current Concepts and Issues (Barry S. Komm and Christopher P. Miller). 12. A New Generation of Drugs in Cancer Treatment: Molecularly Targeted Therapies (Thomas O'Hare, Christopher A. Eide, and Michael W. Deininger). 13. Epidemiology: Identifying Cancer's Causes (James R. Hebert). 14. Consumer Health Information (David Shepro and Catherine N. Norton). Index.