Chronic Complications of Diabetes Mellitus

Dr. Didac Mauricio - Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Institut Universitari per a la Recerca a l’Atencio´ Prima`ria Jordi Gol i Gurina (IDIAP Jordi Gol), Barcelona, Spain; Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau & Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Faculty of Medicine, University of Vic (UVIC/UCC), Vic, Spain Núria Alonso, MD PhD is a staff endocrinologist and head of the diabetes section at the Department of Endocrinology & Nutrition at University Hospital Germans Trias i Pujol Badalona, Spain. She is Assistant Professor at the Faculty of Medicine, Autonomous University of Barcelona. N. Alonso has published a total of 66 scientific articles in indexed journals. Currently, her clinical activity is mainly focused on those conditions that are associated with an increased risk of atheromatous CV disease, with special focus on diabetes mellitus (type 1 and type 2) and familial hypercholesterolemia. In the clinical research field, she is focused on the study of subclinical atheromatosis in patients with diabetes, as well as its association with microvascular complications. In recent years, her scientific activity has also developed on the study of lipotoxicity in diabetes and its association with ectopic fat deposition. She has been principal investigator of several research projects funded by national and international agencies.

Introductory chapters1. Overview on chronic complications of diabetes mellitus2. Epidemiology of chronic complications: A global perspective3. Molecular mechanisms involved in hyperglycemia-induced cellular damage4. Vascular calcification in diabetes mellitus: Molecular mechanisms and clinical implicationsClassical complications5. Pathogenesis of diabetic atherosclerotic cardiovascular disease6. Chronic kidney disease in diabetes: Current concepts7. Diabetic retinopathy: New insights8. Macular edema: A fearful complication of diabetic eye disease9. The eye as a mirror of neuronal impairment10. Diabetic neuropathy: Current issues in diagnosis and preventionNon-classical complications11. Pathophysiological and clinical aspects of non-classical targets of microangiopathy12. Diabetic bone disease: Metabolic and microvascular damage13. Non-alcoholic fatty liver disease: What’s before and what are the consequences14. The diabetic lung15. Diabetic cardiomyopathy: Pathogenetic mechanisms and clinical consequences16. Diabetes-related cognitive impairment and dementia in diabetes17. Cancer in diabetes: Who is who?Outlook in management issues18. Metabolic memory: what is in it?19. HbA1c, or glucose variability for causing diabetic complications?20. Current perspectives on prevention of cardiovascular disease in diabetes21. Prevention and management of chronic kidney disease in diabetes22. Heart failure in diabetes: Current clinical management23. Diabetic eye disease: Novel therapeutic strategies24. Diabetic foot disease: Recent therapeutic progress